The fourth installment of the Mega Man Zero series introduces gameplay changes, but doesn't deviate platforming of its predecessors. Players guide Zero through eight main selectable stages and usually a mini-boss to separate it into two parts. At the end of each level, the player faces one of the game's reploid antagonists.[7]

Besides the past ties Mega Man Zero 4 also includes a new Easy mode, not found in previous installations of the series, giving into responses that the Mega Man Zero series has been too challenging.[8][9] In Easy mode, Zero receives a massive life boost, and can use the Cyber Elf without restrictions. However, Easy mode prevents the changing of the weather, and consequentially the acquiring of EX Skills